Browsing by Subject "drug discovery"
Now showing items 1-9 of 9
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(2016-08-22)Ubiquitination, also known as ubiquitylation, is a major type of post-translational modification (PTM), which is closely associated with numerous cellular processes, such as protein degradation, intracellular trafficking, ...
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(2022-12-07)Phage display is one of the most widely-used techniques to develop peptide therapeutics. Its unique design links the displayed peptides to their encoding DNAs, providing a means for amplifying the peptide library and an ...
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(2019-11-25)Cryptosporidium parvum is a zoonotic parasitic protist and the causative agent of cryptosporidiosis in humans and animals. The main symptom of cryptosporidiosis is diarrhea, which can be severe and life-threatening in ...
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(2021-04-07)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of infectious death worldwide. In particular, the rise in incidence of drug resistant Mtb strains has made it imperative to ...
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(2014-03-18)Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is one of the leading infectious diseases worldwide. The current therapy for drug-sensitive TB is complex and lasts for at least six months. ...
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(2023-06-26)This study presents innovative strategies for protein-targeted drug discovery, offering new avenues for therapeutic development. Initially, to address the pitfall of low selectivity in current high-throughput HDAC ligand ...
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Graph Neural Networks are behind many pharmacological breakthroughs due to their innate ability to learn structural properties of molecules and accelerate high-throughput screening for favorable characteristics that could ...
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(2019-11-21)Considering drug discovery, since the golden era in the mid 1900’s there has been a drastic decrease in the number of novel and useful compounds discovered from environmental samples. Furthermore, due to diminishing returns ...
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(2014-04-01)Mycobacterium tuberculosis (Mtb) is a deadly pathogen that causes the infectious diseases Tuberculosis (TB) in humans. The emergence of drug resistant TB has created an urgent need for the development of new chemotherapeutics ...